MyProteinNet

The identification of the molecular pathways active in specific contexts, such as disease states or drug responses, often requires an extensive view of the potential interactions between a subset of proteins. This view is not easily obtained: it requires the in- tegration of context-specific protein list or expres- sion data with up-to-date data of protein interactions that are typically spread across multiple databases. The MyProteinNet web server allows users to eas- ily create such context-sensitive protein interaction networks. Users can automatically gather and con- solidate data from up to 4 different databases to create a generic protein interaction network (inter- actome). They can score the interactions based on reliability and filter them by user-defined contexts including molecular expression and protein annota- tion. The output of MyProteinNet includes the generic and filtered interactome files, together with a sum- mary of their network attributes. MyProteinNet is par- ticularly geared toward building human tissue in- teractomes, by maintaining tissue expression pro- files from multiple resources. The ability of MyPro- teinNet to facilitate the construction of up-to-date, context-specific interactomes and its applicability to 11 different organisms and to tens of human tis- sues, make it a powerful tool in meaningful analy- sis of protein networks. MyProteinNet is available at https://netbio.bgu.ac.il/myproteinnet